The pathophysiologies of psychiatric disorders remain largely enigmatic, due both to the inherent complexity the complexity of the nervous system and the technical limitations in studying the human brain at cellular resolution. Towards this goal, our approach has been to define clinical observations and epidemiological findings as a starting point for leveraging human genomics, fundamental neuroscience, and human pluripotent stem cell modeling.
Sara Gordillo-Sampedro, Lina Antounians, Wei Wei, Marat Mufteev, Bas Lendemeijer, Steven A. Kushner, Femke M.S. de Vrij, Augusto Zani, James Ellis (2023). iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles. BioRxiv, doi: 10.1101/2023.04.29.538761 [PDF]
Kristel N. Eigenhuis, Hedda B. Somsen, Mark van der Kroeg, Hilde Smeenk, Anne L. Korporaal, Steven A. Kushner, Femke M. S. de Vrij & Debbie L. C. van den Berg (2023) A simplified protocol for the generation of cortical brain organoids. Frontiers in Cellular Neuroscience, doi: 10.1016/j.celrep.2023.112019 [PDF]
Lucia Dutan Polit, Ilse Eidhof, Rhiannon V. McNeill, Katherine M. Warre-Cornish, Cristine Marie Yde Ohki, Natalie Monet Walter, Carlo Sala, Chiara Verpelli, Franziska Radtke, Silvana Galderisi, Armida Mucci, Ginetta Collo, Frank Edenhofer, Maija L. Castrén, János M. Réthelyi, Morten Ejlersen, Sonja Simone Hohmann, Mirolyuba S. Ilieva, Renate Lukjanska, Rugile Matuleviciute, Tanja Maria Michel, Femke M.S. de Vrij, Steven A. Kushner, Bas Lendemeijer, Sarah Kittel-Schneider, Georg C. Ziegler, Doris Gruber-Schoffnegger, Jeroen R. Pasterkamp, Amal Kasri, Marie-Claude Potier, Jürgen A. Knoblich, Oliver Brüstle, Michael Peitz, Emilio Merlo Pich, Adrian J. Harwood, Elsa Abranches, Anna Falk, Anthony C. Vernon, Edna Grünblatt, Deepak P. Srivastava (2023) Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders. Neuroscience Applied, doi: 10.1016/j.nsa.2023.101125 [PDF]
Molly T. Finnerty, Atif Khan, Kai You, Rui Wang, Gyojeong Gu, Deborah Layman, Qingxian Chen, ProfilePaul S. Appelbaum, Todd Lencz, Sander Markx, Steven Kushner, Andrey Rzhetsky (2023) Incidence Measures for Schizophrenia among Commercial Health Insurance and Medicaid Enrollees. medRxiv, doi: 10.1101/2023.02.24.23286405 [PDF]
Washington Post publishes article featuring the clinical work of the SNF center for precision psychiatry
A Washington Post reporter visited the new center for precision psychiatry and mental health at Colu...
Columbia University Launches Center for Precision Psychiatry & Mental Health with $75 Million Grant from the Stavros Niarchos Foundation (SNF)
Columbia University today announced the establishment of the Stavros Niarchos Foundation (SNF) Cent...
Femke de Vrij and Steven Kushner received a H2020 Pathfinder Open grant for the 3D-BrAIn project
3D-BrAIn is an EU-funded research project with partners in Switzerland, Germany and Italy. The proje...
María Pascual García obtains her PhD degree
Maria has succesfully defended her thesis titled "Unveiling Myelination Mechanisms in Schizophrenia"...
Rubicon grant to study xenotransplantation of human neurons
Circuit-level mechanisms of psychiatric disorders remain largely unknown. Investigation of human neu...
Femke de Vrij featured in “Hart van Rotterdam”
Femke de Vrij was featured in an online mini-series about the Erasmus Medical Center, watch the full...
Bas Lendemeijer succesfully defends his PhD thesis
Bas Lendemeijer has succesfully defended his thesis titled "Leveraging human induced pluripotent ste...
Creat2Solve grant awarded to create 3D MICroBrains
Femke de Vrij and Steven Kushner have been awarded a grant to standardize human brain cell cultures ...
ZonMW grant for PSIDER consortium