Sara Gordillo-Sampedro, Lina Antounians, Wei Wei, Marat Mufteev, Bas Lendemeijer, Steven A. Kushner, Femke M.S. de Vrij, Augusto Zani, James Ellis (2023). iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles. BioRxiv, doi: 10.1101/2023.04.29.538761 [PDF]

Kristel N. Eigenhuis, Hedda B. Somsen, Mark van der Kroeg, Hilde Smeenk, Anne L. Korporaal, Steven A. Kushner, Femke M. S. de Vrij & Debbie L. C. van den Berg (2023) A simplified protocol for the generation of cortical brain organoids. Frontiers in Cellular Neuroscience, doi: 10.1016/j.celrep.2023.112019 [PDF]

Lucia Dutan Polit, Ilse Eidhof, Rhiannon V. McNeill, Katherine M. Warre-Cornish, Cristine Marie Yde Ohki, Natalie Monet Walter, Carlo Sala, Chiara Verpelli, Franziska Radtke, Silvana Galderisi, Armida Mucci, Ginetta Collo, Frank Edenhofer, Maija L. Castrén, János M. Réthelyi, Morten Ejlersen, Sonja Simone Hohmann, Mirolyuba S. Ilieva, Renate Lukjanska, Rugile Matuleviciute, Tanja Maria Michel, Femke M.S. de Vrij, Steven A. Kushner, Bas Lendemeijer, Sarah Kittel-Schneider, Georg C. Ziegler, Doris Gruber-Schoffnegger, Jeroen R. Pasterkamp, Amal Kasri, Marie-Claude Potier, Jürgen A. Knoblich, Oliver Brüstle, Michael Peitz, Emilio Merlo Pich, Adrian J. Harwood, Elsa Abranches, Anna Falk, Anthony C. Vernon, Edna Grünblatt, Deepak P. Srivastava (2023) Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders. Neuroscience Applied, doi: 10.1016/j.nsa.2023.101125 [PDF]

Molly T. Finnerty, Atif Khan, Kai You, Rui Wang, Gyojeong Gu, Deborah Layman, Qingxian Chen, Paul S. Appelbaum, Todd Lencz, Sander Markx, Steven Kushner, Andrey Rzhetsky (2023) Incidence Measures for Schizophrenia among Commercial Health Insurance and Medicaid Enrollees. medRxiv, doi: 10.1101/2023.02.24.23286405 [PDF]

X Liu, M Kayser, S A Kushner, H Tiemeier, F Rivadeneira, V W V Jaddoe, W J Niessen, E B Wolvius, G V Roshchupkin (2023) Association between prenatal alcohol exposure and children’s facial shape: a prospective population-based cohort study. Human Reproduction, doi: 10.1093/humrep/dead006 [PDF]

Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Sven van der Vlies, Juliette A. Kamp, Femke M.S. de Vrij, Steven A. Kushner, Graeme C.M. Smith, Simon J. Boulton, Marcel Tijsterman (2023) Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways. Cell Reports, doi: 10.1016/j.celrep.2023.112019 [PDF]

Eline M. P. Poels, Astrid M. Kamperman, Hilmar H. Bijma, Adriaan Honig, Inge L. van Kamp, Steven A. Kushner, Witte J. G. Hoogendijk, Veerle Bergink, Tonya White (2023) Brain development after intrauterine exposure to lithium: A magnetic resonance imaging study in school-age children. Bipolar Disorders, doi: 10.1111/bdi.13297 [PDF]

Sander Lamballais, Gennady V. Roshchupkin, Raymond A. Poot, Steven A. Kushner, M. Arfan Ikram, Hieab H. H. Adams, Henning Tiemeier (2022). The SumRank method efficiently detects valid pleiotropic variants using GWAS summary level data. medRxiv, doi: 10.1101/2022.09.07.22279671 [PDF]

Lisa Bauer, Melanie Rissmann, Feline F. W. Benavides, Lonneke Leijten, Peter van Run, Lineke Begeman, Edwin J. B. Veldhuis Kroeze, Bas Lendemeijer, Hilde Smeenk, Femke M. S. de Vrij, Steven A. Kushner, Marion P. G. Koopmans, Barry Rockx & Debby van Riel (2022) In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants. Acta Neuropathologica Communications, doi: 10.1186/s40478-022-01426-4 [PDF]

B. Lendemeijer, M. Unkel, B. Mossink, S. Hijazi, S.G. Sampedro, G. Shpak, D.E. Slump, M.C.G.N. van den Hout, W.F.J. van IJcken, E.M.J. Bindels, W.J.G. Hoogendijk, N. Nadif Kasri, F.M.S. de Vrij, S.A. Kushner (2022) Rapid specification of human pluripotent stem cells to functional astrocytes. BioRxiv, doi: 10.1101/2022.08.25.505166 [PDF]

J. Castricum, J.H.M. Tulen, A.M. Heuvelmans, G. Geleijnse, D.C.G. Straver, W. Taal, S.A. Kushner, Y. Elgersma (2022) Plasticity of visual evoked potentials in patients with neurofibromatosis type 1. Clinical Neurophysiology, doi: 10.1016/j.clinph.2022.08.009 [PDF]

Hanxin Zhang, Atif Khan, Steven A. Kushner & Andrey Rzhetsky (2022) Dissecting schizophrenia phenotypic variation: the contribution of genetic variation, environmental exposures, and gene–environment interactions. Schizophrenia, doi: 10.1038/s41537-022-00257-5 [PDF]

Lisa R. Steenkamp, Elisabet Blok, Ryan L. Muetzel, Tonya White, Manon H.J. Hillegers, Laura M.E. Blanken, Koen Bolhuis, Henning Tiemeier, Steven A. Kushner (2022) Hallucinations and Brain Morphology Across Early Adolescence: A Longitudinal Neuroimaging Study. Biological Psychiatry, doi: 10.1016/j.biopsych.2022.05.013 [PDF]

Jurate Aleknaviciute, Tavia E. Evans, Elif Aribas, Merel W. de Vries, Eric A. P. Steegers, Mohammad Arfan Ikram, Henning Tiemeier, Maryam Kavousi, Meike W. Vernooij & Steven A. Kushner (2022). Long-term association of pregnancy and maternal brain structure: the Rotterdam Study. European Journal of Epidemiology, doi: 10.1007/s10654-021-00818-5 [PDF]

Lisa Bauer, Brigitta M. Laksono, Femke M.S. de Vrij, Steven A. Kushner, Oliver Harschnitz, Debby van Riel (2022). The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2. Trends in Neuroscience, doi: 10.1016/j.tins.2022.02.006 [PDF]

Jesminne Castricum, Tom K. Birkenhager, Steven A. Kushner, Ype Elgersma & Joke H. M. Tulen (2022). Cortical Inhibition and Plasticity in Major Depressive Disorder. Frontiers in Psychiatry, doi: 10.3389/fpsyt.2022.777422 [PDF]

Mohit Dubey, Maria Pascual-Garcia, Koke Helmes, Dennis D Wever, Mustafa S Hamada, Steven A Kushner, Maarten HP Kole (2022). Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition. eLife, doi: 10.7554/eLife.73827 [PDF]

Youri R. Berends, Joke H.M. Tulen, André I. Wierdsma, Johannes Van Pelt, Ruth Feldman, Orna Zagoory-Sharon, Yolanda B. de Rijk, Steven A. Kushner & Hjalmar J.C. van Marl (2021). Oxytocin and vasopressin in male forensic psychiatric patients with personality disorders and healthy controls. The Journal of Forensic Psychiatry & Psychology, doi: 10.1111/acps.13282 [PDF]

Pablo R Kappen, Johannes Jeekel, Clemens M F Dirven, M Klimek, Steven A Kushner, Robert-Jan Osse, Michiel Coesmans, Marten J Poley, Arnaud J P E Vincent (2021). Music to prevent deliriUm during neuroSurgerY (MUSYC) Clinical trial: a study protocol for a randomised controlled trial. BMJ Open, doi: 10.1136/bmjopen-2020-048270 [PDF]

Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin Strauss, Frank Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Brundu, Karlla W. Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, Jonathan A. Javitch, Bin Xu & Sander Markx (2021). Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. Nature Communications, doi: 10.1038/s41467-021-24358-4 [PDF]

Lisa R. Steenkamp, Henning Tiemeier, Laura M. E. Blanken, Manon H. J. Hillegers, Steven A. Kushner & Koen Bolhuis (2021). Predicting persistence of hallucinations from childhood to adolescence. The British Journal of Psychiatry, 10.1192/bjp.2021.115 [PDF]

Judith R. Homberg, Roger A.H. Adan, Natalia Alenina, Antonis Asiminas, Michael Bader, Tom Beckers, Denovan P. Begg, Arjan Blokland, Marilise E. Burger, Gertjan van Dijk, Ulrich L.M. Eisel, Ype Elgersma, Bernhard Englitz, Antonio Fernandez-Ruiz, Carlos P. Fitzsimons, Anne-Marie van Dam, Peter Gass, Joanes Grandjean, Robbert Havekes, Marloes J.A.G. Henckens, Christiane Herden, Roelof A. Hut, Wendy Jarrett, Kate Jeffrey, Daniela Jezova, Andries Kalsbeek, Maarten Kamermans, Martien J. Kas, Nael Nadif Kasri, Amanda J. Kiliaan, Sharon M. Kolk, Aniko Korosi, S. Mechiel Korte, Tamas Kozicz, Steven A. Kushner, Kirk Leech, Klaus-Peter Lesch, Heidi Lesscher, Paul J. Lucassen, Anita Luthi, Liya Ma, Anne S. Mallien, Peter Meerlo, Jorge F. Mejias, Frank J. Meye, Anna S. Mitchell, Joram D. Mul, Umberto Olcese, Azahara Oliva González, Jocelien D.A. Olivier, Massimo Pasqualetti, Cyriel M.A. Pennartz, Piotr Popik, Jos Prickaerts, Liset M. de la Prida, Sidarta Ribeiro, Benno Roozendaal, Janine I. Rossato, Ali-Akbar Salari, Regien G. Schoemaker, August B. Smit, Louk J.M.J. Vanderschuren, Tomonori Takeuchi, Rixt van der Veen, Marten P. Smidt, Vladyslav V. Vyazovskiy, Maximilian Wiesmann, Corette J. Wierenga, Bella Williams, Ingo Willuhn, Markus Wöhr, Monique Wolvekamp, Eddy A. van der Zee, Lisa Genzel (2021). The continued need for animals to advance brain research. Neuron, doi: 10.1016/j.neuron.2021.07.015 [PDF]

Youri R. Berends, Joke H.M. Tulen, André I. Wierdsma, Yolanda B. de Rijke, Steven A. Kushner, Hjalmar J.C. van Marle (2021). Oxytocin moderates the association between testosterone-cortisol ratio and trustworthiness: A randomized placebo-controlled study. Comprehensive Psychoneuroendocrinology, doi: 10.1016/j.cpnec.2021.100080 [PDF]

Sarah C. Borrie, Ellen Plasschaert, Zsuzsanna Callaerts-Vegh, Akihiko Yoshimura, Rudi D’Hooge, Ype Elgersma, Steven A. Kushner, Eric Legius & Hilde Brems (2021). MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders. Molecular Autism, doi: 10.1186/s13229-021-00458-2 [PDF]

X Liu, M Kayser, S A Kushner, H Tiemeier, F Rivadeneira, V W V Jaddoe, W J Niessen, E B Wolvius, G V Roshchupkin (2021). Association between prenatal alcohol exposure and children’s facial shape: a prospective population-based cohort study. Human Reproduction, doi: 10.1093/humrep/dead006 [PDF]

Lisa Bauer, Bas Lendemeijer, Lonneke Leijten, Carmen W. E. Embregts, Barry Rockx, Steven A. Kushner, Femke M. S. de Vrij, Debby van Riel (2021). Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models. mSphere, doi: 10.1128/mSphere.00270-21 [PDF]

Anna-Sophie Rommel, Nina Maren Molenaar, Janneke Gilden, Steven A. Kushner, Nicola J. Westerbeek, Astrid M. Kamperman, Veerle Bergink (2021). Long-term outcome of postpartum psychosis: a prospective clinical cohort study in 106 women. International Journal of Bipolar Disorders , doi: 10.1186/s40345-021-00236-2 [PDF]

Sylvie L. Lesuis, Niek Brosens, Nathalie Immerzeel, Rolinka J. van der Loo, Miodrag Mitrić, Pascal Bielefeld, Carlos P. Fitzsimons, Paul J. Lucassen, Steven A. Kushner, Michel C. van den Oever (2021). Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population. Biological Psychiatry, doi: 10.1016/j.biopsych.2021.04.010 [PDF]

Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier & Steven A. Kushner (2021).Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation. European Child & Adolescent Psychiatry volume, doi: 10.1007/s00787-021-01727-4 [PDF]

Jason D Hinman, Kathie J Ngo, Deborah Kim, Cidi Chen, Carmela R Abraham, Mohsen Ghanbari, M Arfan Ikram, Steven A Kushner, Riki Kawaguchi, Giovanni Coppola, Kerstin Goth, Saverio Bellusci, Israel Hernandez, Kenneth S Kosik, Brent L Fogel (2021). miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy. Human Molecular Genetics, doi: 10.1093/hmg/ddaa252 [PDF]

Lisa R. Steenkamp, Henning Tiemeier, Koen Bolhuis, Manon H. J. Hillegers, Steven A. Kushner, Laura M. E. Blanken (2021). Peer-reported bullying, rejection and hallucinatory experiences in childhood. Acta Psychiatrica Scandinavica, doi: 10.1111/acps.13282 [PDF]

Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell, Brandon Coombes, Jonathan R. I. Coleman, Zhen Qiao, Thomas D. Als, Tim B. Bigdeli, Sigrid Børte, Julien Bryois, Alexander W. Charney, Ole Kristian Drange, Michael J. Gandal, Saskia P. Hagenaars, Masashi Ikeda, Nolan Kamitaki, Minsoo Kim, Kristi Krebs, Georgia Panagiotaropoulou, Brian M. Schilder, Laura G. Sloofman, Stacy Steinberg, Vassily Trubetskoy, Bendik S. Winsvold, HUNT All-In Psychiatry, …Ole A. Andreassen(2020). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics, doi: 10.1038/s41588-021-00857-4 [PDF]

Van Hilten A, Kushner SA, Kayser M, Ikram MA, Adams HH, Klaver CC, Niessen WJ, Roshchupkin GV (2020). GenNet framework: interpretable neural networks for phenotype prediction. bioRxiv, doi: 10.1101/2020.06.19.159152 [PDF]

De Jong JO, Llapashtica C, Strauss K, Provenzano F, Sun Y, Cortese GP, Brigatti KW, Corneo B, Migliori B, Kushner SA, Kellendonk C, Javitch JA, Xu B, Markx S (2020). Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. bioRxiv, doi: 10.1101/739391 [PDF]

Castricum J, Tulen JHM, Taal W, Ottenhoff MJ, Kushner SA, Elgersma Y (2020). Motor cortical excitability and plasticity in patients with neurofibromatosis type 1. Clinical Neurophysiology, doi: 10.1016/j.clinph.2020.08.016 [PDF]

Genzel L, Adan R, Berns A, van den Beucken J, Blokland A, Boddeke EH, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TC, Dam A-Mv, Deen PM, van Dijk KW, Eggen BJL, Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP, Frieling W, Haagmans B, Heesters BA, Henckens M, Herfst S, Hol E, van den Hove D, de Jonge MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer J, Kersten S, Kiliaan AJ, Kooij TW, Kooijman S, Koopman W, Korosi A, Krugers HJ, Kuiken T, Kushner SA, Langermans JA, Lesscher H, Lucassen PJ, Lutgens E, Netea MG, Noldus LP, van der Meer JW, Meye FJ, Mul JD, van Oers K, Olivier JD, Pasterkamp RJ, Philippens IH, Prickaerts J, Pullox B, Rensen PC, van Rheenen J, van Rij RP, Ritsma L, Rockx BH, Roozendaal B, van Schothorst EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJ, de Vries T, de Vrij FMS, van Wezel R, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current Biology, doi:10.1016/j.cub.2020.08.030 [PDF]

El Marroun H, Zou R, Leeuwenburg M, Steegers E, Reiss I, Muetzel RL, Kushner SA, Tiemeier H (2020). Association of Gestational Age at Birth With Brain Morphometry. JAMA Pediatrics, doi: 10.1001/jamapediatrics.2020.2991 [PDF]

Zampeta IF, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, de Vrij FMS, Kushner SA, Distel B, Elgersma Y (2020). Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms. Human Molecular Genetics, doi: 10.1093/hmg/ddaa194 [PDF]

Steenkamp LR, Bolhuis K, Blanken LM, Luijk MP, Hillegers MH, Kushner SA, Tiemeier H (2020). Psychotic experiences and future school performance in childhood: a population-based cohort study. Journal of Child Psychology and Psychiatry, doi: 10.1111/jcpp.13281 [PDF]

Tran Mau-Them F, Moutton S, Racine C, Vitobello A, Bruel AL, Nambot S, Kushner SA, de Vrij FMS, Lehalle D, Jean-Marçais N, Lecoquierre F, Delanne J, Thevenon J, Poe C, Jouan T, Chevarin M, Geneviève D, Willems M, Coubes C, Houcinat N, Masurel-Paulet A, Mosca-Boidron AL, Tisserant E, Callier P, Sorlin A, Duffourd Y, Faivre L, Philippe C, Thauvin-Robinet C (2020). Second-tier trio exome sequencing after negative solo clinical exome sequencing: an efficient strategy to increase diagnostic yield and decipher molecular bases in undiagnosed developmental disorders. Human Genetics , doi: 10.1007/s00439-020-02178-8 [PDF]

Vinueza-Veloz MF, Martin-Román C, Robalino-Valdivieso MP, White T, Kushner SA, De Zeeuw CI (2020). Genetic risk for Alzheimer’s disease in children: evidence from early-life IQ and brain white-matter microstructure. Genes, Brain and Behavior, doi: 10.1111/gbb.12656 [PDF]

Gilden J, Kamperman AM, Munk-Olsen T, Hoogendijk WJG, Kushner SA, Bergink V (2020). Long-term outcomes of postpartum psychosis and mania: a systematic review and meta-analysis. Journal of Clinical Psychiatry, doi: 10.4088/JCP.19r12906 [PDF]

Zhang Y, Venkateswaran S, Higuera GA, Nath S, Shpak G, Matray J, Fratila-Apachitei LE, Zadpoor AA, Kushner SA, Bradley M, De Zeeuw CI (2020). Synthetic polymers provide a robust substrate for functional neuron culture. Advanced Healthcare Material, doi: 10.1002/adhm.201901347 [PDF]

Ottenhoff MJ, Fani L, Erler NS, Castricum J, Obdam I, Van der Vaart MHT, Kushner SA, De Wit MCY, Elgersma Y, Tulen JHM (2019). Within-subject consistency of TMS paired associative stimulation as assessed by linear mixed models. bioRxiv, doi: 10.1101/2020.06.19.159152 [PDF]

Xiong Z, Dankova G, Howe LJ, Lee MK, Hysi PG, de Jong MA, Zhu G, Adhikari K, Li D, Li Y, Pan B, Feingold E, Marazita ML, Shaffer JR, McAloney K, Xu SH, Jin L, Wang S, de Vrij FM, Lendemeijer B, Richmond S, Zhurov A, Lewis S, Sharp GC, Paternoster L, Thompson H, Gonzalez-Jose R, Bortolini MC, Canizales-Quinteros S, Gallo C, Poletti G, Bedoya G, Rothhammer F, Uitterlinden AG, Ikram MA, Wolvius E, Kushner SA, Nijsten TE, Palstra RT, Boehringer S, Medland SE, Tang K, Ruiz-Linares A, Martin NG, Spector TD, Stergiakouli E, Weinberg SM, Liu F, Kayser M; International Visible Trait Genetics (VisiGen) Consortium (2019). Novel genetic loci affecting facial shape variation in humans. Elife, doi: 10.7554/eLife.49898 [PDF]

Stedehouder J, Brizee D, Slotman JA, Pascual-Garcia M, Leyrer ML, Bouwen BL, Dirven CM, Gao Z, Berson DM, Houtsmuller AB, Kushner SA (2019). Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex. Elife, doi: 10.7554/eLife.48615 [PDF]

Heimer G, van Woerden GM, Barel O, Marek-Yagel D, Kol N, Munting JB, Borghei M, Atawneh OM, Nissenkorn A, Rechavi G, Anikster Y, Elgersma Y, Kushner SA, Ben Zeev B (2019). Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia. Human Mutation, doi: 10.1002/humu.23945 [PDF]

Ghanbari M, Munshi ST, Ma B, Lendemeijer B, Bansal S, Adams HH, Wang W, Goth K, Slump DE, van den Hout MCGN, van IJcken WFJ, Bellusci S, Pan Q, Erkeland SJ, de Vrij FMS, Kushner SA, Ikram MA (2019). A functional variant in the miR-142 promoter modulating its expression and conferring risk of Alzheimer disease. Human Mutation, doi: 10.1002/humu.23872 [PDF]

Avagliano Trezza R, Sonzogni M, Bossuyt SNV, Zampeta FI, Punt AM, van den Berg M, Rotaru DC, Koene LMC, Munshi ST, Stedehouder J, Kros JM, Williams M, Heussler H, de Vrij FMS, Mientjes EJ, van Woerden GM, Kushner SA, Distel B, Elgersma Y (2019). Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome. Nature Neuroscience , doi: 10.1038/s41593-019-0425-0 [PDF]

Berends YR, Tulen JHM, Wierdsma AI, van Pelt J, Feldman R, Zagoory-Sharon O, de Rijke YB, Kushner SA, van Marle HJC (2019). Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males. Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2019.03.027 [PDF]

Rao-Ruiz P, Couey JJ, Marcelo IM, Bouwkamp CG, Slump DE, Matos MR, van der Loo RJ, Martins GJ, van den Hout M, van IJcken WF, Costa RM, van den Oever MC, Kushner SA (2019). Engram-specific transcriptome profiling of contextual memory consolidation. Nature Communications, doi: 10.1038/s41467-019-09960-x [PDF]

Berends YR, Tulen JHM, Wierdsma AI, van Pelt J, Kushner SA, van Marle HJC (2019). Oxytocin, vasopressin and trust: Associations with aggressive behavior in healthy young males. Physiology & Behavior, doi: 10.1016/j.physbeh.2019.02.027 [PDF]

Bolhuis K, Tiemeier H, Jansen PR, Muetzel RL, Neumann A, Hillegers MHJ, van den Akker ETL, van Rossum EFC, Jaddoe VWV, Vernooij MW, White T, Kushner SA (2019). Interaction of schizophrenia polygenic risk and cortisol level on pre-adolescent brain structure. Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2018.12.231 [PDF]

Rao-Ruiz P, Yu J, Kushner SA, Josselyn SA (2019). Neuronal competition: microcircuit mechanisms define the sparsity of the engram. Current Opinion in Neurobiology, doi: 10.1016/j.conb.2018.10.013 [PDF]

Bolhuis K, Muetzel RL, Stringaris A, Hudziak JJ, Jaddoe VWV, Hillegers MHJ, White T, Kushner SA, Tiemeier H (2019). Structural Brain Connectivity in Childhood Disruptive Behavior Problems: A Multidimensional Approach. Biological Psychiatry doi: 0.1016/j.biopsych.2018.07.005 [PDF]

Aleknaviciute J, Tulen JHM, de Rijke YB, van der Kroeg M, Kooiman CG, Kushner SA (2018). No evidence for an interaction between 5-HTTLPR genotype and early life adversity in cortisol responsivity to psychosocial stress in women. BJPsych Open, doi: 10.1192/bjo.2018.23 [PDF]

Proietti Onori M, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, Küry S, Elgersma Y, van Woerden GM (2018). The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function. Human Mutation, doi: 10.1002/humu.23647 [PDF]

Bolhuis K, Kushner SA, Yalniz S, Hillegers MHJ, Jaddoe VWV, Tiemeier H, El Marroun H (2018). Maternal and paternal cannabis use during pregnancy and the risk of psychotic-like experiences in the offspring. Schizophrenia Research,doi: 10. 1016/j.schres.2018.06.067 [PDF]

Woodruff G, Bouwkamp CG, de Vrij FM, Lovenberg T, Bonaventure P, Kushner SA, Harrington AW (2018). The zinc transporter SLC39A7(ZIP7) is essential for regulation of cytosolic zinc levels. Molecular Pharmacology, doi: 10.1124/mol.118.112557 [PDF]

Poels EM, Schrijver L, Kamperman AM, Hillegers MH, Hoogendijk WJ, Kushner SA, Roza SJ (2018). Long term neurodevelopmental consequences of intrauterine exposure to lithiumand antipsychotics: a systematic review and meta-analysis. European Child & Adolescent Psychiatry, doi: 10.1007/s00787-018-1177-1 [PDF]

De Vrij FMS*, Bouwkamp CG*, Gunhanlar N*, Shpak G, Lendemeijer B, Baghdadi M, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PM, Hoencamp E, Bergink V, GROUP Study Consortium, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD,Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA (2018). Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia. Molecular Psychiatry, doi: 10.1038/s41380-017-0004-2 [PDF]

Bolhuis K, Verhoeff ME, Blanken LM, Cibrev D, Jaddoe VWV, Verhulst FC, Hillegers MHJ, Kushner SA, Tiemeier H (2018). Psychotic-like experiences in pre-adolescence: what precedes the antecedent symptoms of severe mental illness? Acta Psychiatrica Scandinavica, 138(1): 15-25 [PDF]

Bouwkamp CG*, Afawi Z*, Fattal-Valevski A*, Quadri M, Breedveld GJ, Masalha R, Mandel H, Abu Tailakh M, van Eijcken WF, Vernooij MW, Bonifati V, Kushner SA (2018). ACO2homozygous missense mutation associated with complicated hereditary spastic paraplegia. Neurology Genetics, 4(2): e223 [PDF]

Stedehouder J*, Brizee D*, Shpak G, Kushner SA (2018). Activity-dependent myelination of parvalbumin interneurons mediated by axonal morphological plasticity. Journal of Neuroscience, 38(15): 3631-3642 [PDF]

García-León JA, Kumar M, Boon R, Chau D, One J, Wolfs E, Eggermonts K, Berckmans P, Gunhanlar N, De Vrij FM, Lendemeijer B, Pavie B, Corthout N, Kushner SA, Carlos J, Dávila C, Lambrichts I, Hu WS, Verfaillie CM (2018). Single transcription factor based generation of oligodendrocytes from human pluripotent stem cells. Stem Cell Reports, 10(2): 655-672 [PDF]

De Witte LD, Snijders G, Litjens M, Kamperman AM, Kushner SA, Kahn RS, Bergink V(2018). Are infectious agents involved in the pathogenesis of postpartum psychosis? Journal of Affective Disorders, 229:141-144 [PDF]

Amin N*, de Vrij FMS*, Baghdadi M*, Brouwer RW, van Rooij J, Jovanonva O, Uitterlinden AG, Hofman A, Janssen HL, Murad SD, Kraaij R, Stedehouder J, van IJckenWF, Tiemeier HW, Kushner SAξ, van Duijn CMξ (2018). A rare missense variant in RCL1 segregates with depression in extended families.Molecular Psychiatry, 23(5): 1120-1126 [PDF]

Gunhanlar N*, Shpak G*, van der Kroeg M, Gouty-Colomer LA, Munshi ST, Lendemeijer B, Ghazvini M, Dupont C, Hoogendijk WJ, Gribnau J, de Vrij FMSξ, Kushner SAξ (2018). A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells. Molecular Psychiatry, 23(5): 1336-1344 [PDF]

Bouwkamp CG*, Kievit AJ*, Markx S*, Friedman JI*, van Zutven L, van Minkelen R, Vrijenhoek T, Xu B, Sterrenburg-van de Nieuwegiessen I, Veltman JA, Bonifati V, Kushner SA (2017). Copy number variation in syndromicforms of psychiatric illness: The emerging value of clinical genetic testingin psychiatry. American Journal of Psychiatry, 174(11): 1036-1050 [PDF]

Stedehouder J, Couey JJ, Brizee D, Hosseini B, Slotman JA, Dirven CMF, Shpak G, Houtsmuller AB, Kushner SA (2017). Fast-spiking parvalbumin interneurons are frequently myelinated in the cerebral cortex of mice and humans. Cerebral Cortex, 27(10): 5001-5013 [PDF]

Higuera GA, Iaffaldano G, Bedar M, Shpak G, Broersen R, Munshi ST, Du Pont C, Gribnau J, de Vrij FMS, Kushner SA, De Zeeuw CI (2017). An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivomaturation in the adult mouse cerebellum. Scientific Reports, 7(1):8863.[PDF]

Anfasa F*, Siegers JY*, van der Kroeg M, Mumtaz N, Stalin Raj V, de Vrij FMS, Widagdo W, Gabriel G, Salinas S, Simonin Y, Reusken C, Kushner SA, Koopmans MPG, Haagmans B, Martina BEE, van Riel D (2017). Phenotypic differences between Asian and African lineage Zika viruses in human neural progenitor cells. mSphere, 2(4): e00292-17.[PDF]

Bolhuis K, Lubke GH, van der Ende J, Bartels M, van Beijsterveldt CEM, Lichtenstein P, Larsson H, Jaddoe VWV, Kushner SA, Verhulst FC, Boomsma DI, Tiemeier H (2017). Disentangling heterogeneity of childhood disruptive behavior problems into dimensions and subgroups. Journal of the American Academy of Child and Adolescent Psychiatry, 56(8): 678-686.[PDF]

Wesseloo R, WierdsmaAI, Van Kamp IL, Hoogendijk WJ, Munk-Olsen T, Kushner SA, Bergink V (2017). Lithium blood levels and dosing strategies during pregnancy and the postpartum period. British Journal of Psychiatry, 211(1): 31-36.[PDF]

Van Esbroeck ACM*, Janssen APA*, Cognetta AB 3rd*, Ogasawara D*, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SAξ, van der Stelt Mξ(2017). Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science, 356(6342): 1084-1087.[PDF]

Lukoshe A, van den Bosch G, van der Lugt A, Kushner SA, Hokken-Koelega AC, White T (2017). Aberrant white matter microstructure in children and adolescents with the subtype of Prader Willi Syndrome at high risk for psychosis. Schizophrenia Bulletin, 43(5): 1090-1099.[PDF]

Wesseloo R, Liu X, Clark C, Kushner SA, Munk-Olsen T, Bergink V (2017). Risk of postpartum episodes in women with bipolar disorder after lamotrigine or lithium use during pregnancy: a population-based cohort study. Journal of Affective Disorders, 218: 394-397.[PDF]

Schreiber J*, Grimbergen LA*, Overwater I, van der Vaart MT, Stedehouder J, Schuhmacher AJ, Guerra C, Kushner SA, Jaarsma D, Elgersma Y (2017). Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models. Scientific Reports, 7(1): 1256.[PDF]

Vanhauwaert R, Kuenen S, Masius R, Bademosi A, Manetsberger J, Schoovaerts N, Bounti L, Gontcharenko S, Swerts J, Vilain S, Picillo M, Barone P, Munshi ST, de Vrij FM, Kushner SA, Gounko NV, Mandemakers W, Bonifati V, Meunier F, Soukup SF, Verstreken P (2017). The SAC1 domain in Synaptojaninis required for autophagosome maturation at presynaptic terminals. The EMBO Journal, 36(10): 1392-1411.[PDF]

Zhou X, Huang F, Xu L, Lin Z, De Vrij FM, Ayo-Martin AC, van der Kroeg M, Zhao M, Yin Y, Wang W, Cao W, Wang Y, Kushner SA, Peron JM, Alric L, de Man RA, Jacobs BC, van Eijk JJ, Aronica EM, Sprengers D, Metselaar HJ, de Zeeuw CI, Dalton HR, Kamar N, Peppelenbosch MP, Pan Q (2017). Hepatitis E virus infects neurons and brains. Journal of Infectious Diseases, 215(8): 1197-1206.[PDF]

Aleknaviciute J, Tulen JHM, De Rijke YB, Bouwkamp CG, van der Kroeg M, Timmermans M, Wester VL, Bergink V, Hoogendijk WJG, Tiemeier H, van Rossum EFC, Kooiman CG, Kushner SA (2017). The levonorgestrel-releasing intrauterine device potentiates stress reactivity. Psychoneuroendocrinology, 80(6): 39-45.[PDF]

Stedehouder J, Kushner SA (2017). Myelination of parvalbumin interneurons: A parsimonious locus of pathophysiological convergence in schizophrenia. Molecular Psychiatry, 22(1):4-12.[PDF]

Burgerhout KM, Kamperman AM, Roza SJ, Lambregtse-Van den Berg ML, Koorengevel KM, Hoogendijk WJ, Kushner SA, BerginkV (2017). Functional Recovery After Postpartum Psychosis: A Prospective Longitudinal Study. Journal of Clinical Psychiatry, 78(1):122-128.[PDF]

Amin N, Jovanova O, Adams H, Dehghan A, Kavousi M, Vernooij MW, Peters R, de Vrij FM, van der Lee S, van Rooij J, van Leeuwen EM, Chaker L, Demirkan A, Hofman A, Brouwer R, Uitterlinden AG, van Ijcken W, Kraaij R, Niessen WJ, Franco OH, Kushner SA, Ikram MA, Tiemeier H, van Duijn CM (2017). Exome sequencing in a large population-based study reveals a rare Asn396Servariant in the LIPGgene associated with depressive symptoms. Molecular Psychiatry,22(4): 537-543.[PDF]

Bouwkamp CG, Kievit AJ, Olgiati S, Breedveld GJ, Coesmans M, Wouters C, Bonifati V, Kushner SA (2017). A balanced translocation disrupting BCL2L10and PNLDC1segregates with affective psychosis. American Journal of Medical Genetics Part B, 174(3): 214-219.[PDF]

Aleknaviciute J, Tulen JH, Timmermans M, de Rijke YB, van Rossum EF, de Jong F, Kushner SA (2016). Adrenocorticotropic hormone elicits gonadotropin secretion in premenopausal women. Human Reproduction, 31(10): 2360-2368.[PDF]

Peter S, Ten Brinke MM, Stedehouder J, Reinelt CM, Wu B, Zhou H, Zhou K, Boele HJ, Kushner SA, Lee MG, Schmeisser MJ, BoeckersTM, Schonewille M, Hoebeek FE, De Zeeuw CI (2016). Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice. Nature Communications, 7: 12627.[PDF]

Aleknaviciute J, Tulen JH, Kamperman AM, de Rijke YB, Kooiman CG, Kushner SA (2016). Borderline and Cluster C personality disorders manifest distinct physiological responses to psychosocial stress. Psychoneuroendocrinology, 72: 131-138.[PDF]

Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA, Bergink V(2016). Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression: Restoration of T regulatory cell populations after antidepressant therapy. Psychopharmacology, 233(9): 1679-88.[PDF]

Gouty-Colomer LA, Hosseini B, Marcelo IM, Schreiber J, Slump DE, Yamaguchi S, Houweling AR, Jaarsma D, Elgersma Y, Kushner SA (2016). Arcexpression identifies the lateral amygdala fear memory trace. Molecular Psychiatry, 21(3): 364-375.[PDF]

Wesseloo R, Kamperman AM,Munk-Olsen T, Pop VJ,Kushner SA, Bergink V (2016). Risk of Postpartum Relapse in Bipolar Disorder and Postpartum Psychosis: A Systematic Review and Meta-Analysis. American Journal of Psychiatry, 173(2):117-127.[PDF]

Veen C, Myint AM, Burgerhout KM, Schwarz MJ, Schütze G, Kushner SA, Hoogendijk WJ, Drexhage HA, Bergink V (2016). Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression. Journal of Affective Disorders, 189: 298-305.[PDF]

Bergink V, Munk-Laursen T, Winther-Johannsen BM, Kushner SA, Meltzer-Brody S, Munk-Olsen T (2015). Preeclampsia and first-onset postpartum psychiatric episodes: A Danish population-based cohort study. Psychological Medicine, 45(16): 3481-3489.[PDF]

Bergink V, Armangue T, Titulaer M, Markx S, Dalmau J, Kushner SA (2015). Autoimmune encephalitis in postpartum psychosis. American Journal of Psychiatry, 172(9):901-908.[PDF]

Pessôa BS, Slump DE, Ibrahimi K, Grefhorst A, van Veghel R, Garrelds IM, Roks AJ, Kushner SA, Danser AH, van Esch JH (2015). Angiotensin II type 2 receptor-and acetylcholine-mediated relaxation: the essential contribution of female sex hormones and chromosomes. Hypertension, 66(2): 396-402.[PDF]

Omrani A, van der Vaart MT, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y (2015). HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Molecular Psychiatry, 20(11): 1311-1321.[PDF]

Silva-Santos S, van Woerden GM, Bruinsma CF,Mientjes E, Jolfaei MA, Distel B, Kushner SA, Elgersma Y (2015). Ube3a reinstatement identifies distinct treatment windows in Angelman syndrome model mice. Journal of Clinical Investigation, 125(5): 2069-2076.[PDF]

Bergink V, Burgerhout KM, Koorengevel KM, Lambregtse-van den Berg MP, Kushner SA (2015). Treatment of psychosis and mania in the postpartum period. American Journal of Psychiatry, 172(2): 115-123.[PDF]

Van den Berg WE, Lamballais S, Kushner SA (2015). Sex-specific mechanism of social hierarchy in mice. Neuropsychopharmacology, 40(6): 1364-1372.[PDF]

De Esch CE, van den Berg WE, Buijsen RA, Jaafara IA, Nieuwenhuizen-Bakkera IM, Gasparini F, Kushner SA*, Willemsen R*(2015). Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test. Neurobiology of Disease, 75(3): 31-39.[PDF]

Ibrahimi K, van Oosterhout WP, van Dorp W, Danser AH, Garrelds IM, Kushner SA, Lesaffre EM, Terwindt GM, Ferrari MD, van den Meiracker AH, MaassenVanDenBrink A (2015). Reduced trigeminovascular cyclicity in patients with menstrually related migraine.Neurology, 84(2): 125-131.[PDF]

De Esch CE, GhazviniM, Loos F, Schelling-Kazaryan N, WidagdoW, MunshiST, van der WalE, Douben H, Gunhanlar N, KushnerSA, PijnappelWW, de Vrij FM, Geijsen N, GribnauJ, Willemsen R (2014). Epigenetic characterization of the FMR1 promoter in induced pluripotentstem cells from human fibroblasts carrying an unmethylated full mutation. Stem Cell Reports, 3(4): 548-555.[PDF]

Achterberg KG, Buitendijk GH, Kool M, Goorden SM, Post L, Slump DE, Silva AJ, van Woerden GM, Kushner SA*, Elgersma Y*(2014). Temporal and region-specific requirements of CaMKII in spatial and contextual learning. Journal of Neuroscience, 34(34): 11180-11187.[PDF]

Yiu AP, Mercaldo V, Yan C, Richards B, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW, Josselyn SA(2014). Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training. Neuron, 83(3): 722-735.[PDF]

Bergink V, Kushner SA (2014). Lithium during pregnancy. American Journal of Psychiatry, 171(7): 712-715.[PDF]

Ellegood J, Markx S, Lerch JP,Steadman PE, Genç C, Provenzano F, Kushner SA, Henkelman RM, Karayiorgou M, Gogos JA (2014). Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion. Molecular Psychiatry, 19(1): 99-107.[PDF]

Galliano E, Potters JW, Elgersma Y, Wisden W, Kushner SA, De Zeeuw CI, Hoebeek FE (2013). Synaptic transmission and plasticity at inputs to murine cerebellar Purkinje cells are largely dispensable for standard nonmotor tasks. Journal of Neuroscience, 33(31): 12599-12618.[PDF]

Bergink V, Burgerhout KM, Weigelt K, de Witt HJ, Pop VJ, Kushner SA, Drexhage HA (2013). Immune system dysregulation in first-onset postpartum psychosis. Biological Psychiatry, 73(10): 1000-1007.[PDF]

Bergink V, Bouvy PF, Vervoort JS, Koorengevel KM, Steegers EA, Kushner SA (2012).Prevention of Postpartum Psychosis and Mania in Women at High Risk. American Journal of Psychiatry, 169(6): 609-615.[PDF]

Bergink V, Lambregtse-van den Berg MP, Koorengevel K, Kupka R, Kushner SA (2011). First-onset psychosis occurring in the postpartum period: a prospective cohort study. Journal of Clinical Psychiatry, 72(11): 1531-1537.[PDF]

Akers KG, Kushner SA, Leslie AT, Clarke L, van der Kooy D, Lerch JP, Frankland PW (2011). Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice. Molecular Brain, 4: 29.[PDF]

Bergink V, Kushner SA, Pop V, Kuijpens H, Lambregtse-van den Berg MP, Drexhage RC, Wiersinga W, Nolen WA, Drexhage HA (2011). Prevalence of autoimmune thyroid dysfunction in postpartum psychosis. British Journal of Psychiatry,198(4): 264-268.[PDF]

Van Woerden GM, Hoebeek FE, Gao Z, Nagaraja RY, Hoogenraad CC, Kushner SA, Hansel C, de Zeeuw CI, Elgersma Y (2009). CaMKII controls the direction of plasticity at parallel fiber–Purkinje cell synapses. Nature Neuroscience, 12(7): 823-825.[PDF]

Han JH, Kushner SA, Yiu AP, Hsiang HL, BuchT, Waisman A, Bontempi B, Neve RL, Frankland PW, Josselyn SA (2009). Selective erasure of a fear memory. Science,323(5920): 1492-1496.[PDF]

Krab LC, de Goede-Bolder A, Aarsen FK, Pluijm SMF, Bouman MJ, van der Geest JN, Lequin M, Catsman CE, Arts WFM,Kushner SA, Silva AJ, de Zeeuw CI, Moll HA, Elgersma Y (2008). Effect of simvastatin on cognitive functioning in children with Neurofibromatosis type 1: a randomized controlled trial. JAMA, 300(3): 287-294.[PDF]

Han JH*, Kushner SA*, Yiu AP, Cole CA, Matynia A, Brown RA, Neve R, Guzowski JF, Silva AJ, Josselyn SA (2007). Neuronal competition and selection during memory formation. Science, 316(5823): 457-460.[PDF]

Kushner SA, Prudic J, Louis ED (2007). Transient improvement of essential tremor during electroconvulsive therapy. Journal of ECT, 23(2): 99-102.[PDF]

Li W, Cui Y, Kushner SA, Brown RA, Jentsch JD, Frankland PW, Cannon TD, Silva AJ (2005). The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Current Biology, 15(21): 1961-1967.[PDF]

Kushner SA*, Elgersma Y*, Murphy GG, Jaarsma D, van Woerden GM, Hojjati MR, Cui Y, LeBoutillier JC, Marrone DF, Choi ES, De Zeeuw CI, Petit TL, Pozzo-Miller L, Silva AJ (2005). Modulation of presynaptic plasticity and learning by the H-ras / extracellular signal-regulated kinase / synapsin I signaling pathway. Journal of Neuroscience, 25(42): 9721-34. [PDF]